Cellular Biology, Prions
David Garcia and researchers in his lab examine the molecular activities of abnormal, or prion, proteins, and epigenetic traits that influence how a cell responds to stress and new environments, which has major impacts on its evolutionary success, and its ability to transform into diseased states. In 2022, he received an NIH Maximizing Investigators’ Research Award. He was a postdoctoral fellow at Stanford after earning his PhD at Massachusetts Institute of Technology. He joined the UO faculty in 2018.
Autoimmunity, Biology, Cancer, Cellular Biology, Children's Health, Genomics, Health, Immune System, Immunology, Inflammation, Innate Immune System, Monocytes, Women's Health
LJI Associate Professor Sonia Sharma, Ph.D., is an expert in using unbiased, genome-scale approaches to unravel innate immunity, the body’s early immune response to microbial pathogens and neoplastic cells. Innate immunity has also been implicated as a common causal factor in many inflammatory, allergic and autoimmune diseases. Dr. Sharma integrates cutting-edge genetics, biochemistry, cell biology, computational and translational approaches to define the key genetic mechanisms regulating cellular innate immunity and determine how they impact human health and disease.
Dr. Sharma has an outstanding record of research accomplishments, including high impact discoveries published in top scientific journals. Her work has made her an internationally recognized expert in the use of high throughput, genome scale approaches, in particular RNA interference and CRISPR/Cas9, to dissect complex cellular signaling pathways and questions of immunological relevance. Her use of these technologies is a powerful tool that can be applied to any cellular pathway or disease process.
Dr. Sharma also directs the La Jolla Institute for Immunology's Sex-Based Differences in the Immune System Initiative, which aims to shed light on why many diseases affect men and women differently.