News Curated ��Ҵ�ý Channel: Grant Funded News

Scientists Identify Agent of Transformation In Protein Blobs That Morph From Liquid to Solid

Rutgers University-New Brunswick — Fri, 18 Apr 2025 15:00:00 EST

An international research collaboration led by Rutgers University-New Brunswick scientists that examined microscopic blobs of protein found in human cells has discovered that some morph from an almost honey-like substance to a hard candy-like solid. These mysterious droplets, known as biomolecular condensates, solidify when they carry a high proportion of the protein alpha-synuclein, the scientists reported in Science Advances. Clumps of alpha-synuclein are commonly found in the brain cells of people with Parkinson's disease, a neurodegenerative brain disorder.

Study Highlights Gaps in Firearm Suicide Prevention Among Women

Ohio State University — Fri, 18 Apr 2025 11:00:51 EST

At a time of increased gun ownership among women, a new study found just under 4 in 10 women who died by firearm suicide had no documented history of mental or physical health problems, highlighting a need for prevention strategies tailored to at-risk women.

Monell Center Study Identifies GLP-1 Therapies as a Possible Treatment for Rare Genetic Disorder Bardet-Biedl Syndrome

Monell Chemical Senses Center — Thu, 17 Apr 2025 20:45:00 EST

Monell Center investigators identified that GLP-1R agonists, a class of drugs currently used to treat type-2 diabetes and obesity, as a promising therapeutic for managing the metabolic complications associated with Bardet-Biedl Syndrome (BBS), a rare genetic disorder characterized by early-onset obesity, compulsive eating, and cognitive impairments. They used a genetically engineered mouse model of BBS that displayed the hallmark features of the condition.

Frequent Use of Antibiotics in Infants and Young Children May Increase Risk for Asthma, Allergies and Other Conditions

Rutgers University-New Brunswick — Wed, 16 Apr 2025 09:20:13 EST

Rutgers Health researchers highlight the connection between early repeated antibiotic use how it impacts the digestive microbiome

Moffitt Study Shows New Immune Boost Could Expand Access to Cancer Immunotherapy

Moffitt Cancer Center — Fri, 11 Apr 2025 10:15:36 EST

Researchers at Moffitt Cancer Center have found that tapping into the body's own immune system and activating a type of immune cell known as B cells, could be the key to boosting the effectiveness of tumor-infiltrating lymphocyte, or TIL therapy. Results of their study were published in the Journal for Immunotherapy of Cancer.

Scientists Develop Process Using Molecules in the Cell to Identify Environmental Signals

Rutgers University-New Brunswick — Thu, 10 Apr 2025 20:10:31 EST

Scientists have transformed RNA, a biological molecule present in all living cells, into a biosensor that can detect tiny chemicals relevant to human health. Research by Rutgers University-New Brunswick scientists centers on RNA, a nucleic acid that plays a crucial role in most cellular processes. Their work is expected to have applications in the surveillance of environmental chemicals and, ultimately, the diagnosis of critical diseases including neurological and cardiovascular diseases and cancer.

Researchers Create 'Wiring Diagram' for Key Songbird Brain Region

UT Southwestern Medical Center — Thu, 10 Apr 2025 18:15:06 EST

Much like human beings, songbirds learn how to vocalize from their parents. Males imitate songs from their fathers and then sing to attract mates.

UCLA Researchers Identify Precision Medicine Approach for Preventing Kidney Failure

University of California, Los Angeles (UCLA), Health Sciences — Wed, 09 Apr 2025 14:00:00 EST

UCLA researchers have identified collagen as a key factor in kidney fibrosis, revealing its potential as a biomarker to predict chronic kidney disease progression. A repurposed anti-cancer drug, Cilengitide, was found to reduce kidney scarring and slow disease progression in preclinical models, suggesting a possible precision medicine approach for high-risk patients.

A Comprehensive Map of the Human Cell

University of California San Diego — Wed, 09 Apr 2025 11:00:00 EST

By mapping the subcellular architecture of tumor cells, researchers can better understand how mutations cause cancer.

Researchers' Study Show Advancements in GP38 Contributions to CCHFV and Monoclonal Antibody Therapies

U.S. Army Medical Research Institute of Infectious Diseases — Tue, 08 Apr 2025 21:15:15 EST

A recent study published in Science Translational Medicine involving scientists from the U.S. Army Medical Research Institute of Infectious Diseases in collaboration with scientists from the Albert Einstein College of Medicine and the University of California-Berkeley have advanced discoveries surrounding the viral glycoprotein GP38 expressed by the Crimean-Congo hemorrhagic fever virus (CCHFV).

Immune Cell Research Identifies Potential New Target for Treating Cancer and Autoimmune Disease

Johns Hopkins Medicine — Tue, 08 Apr 2025 20:45:12 EST

In a study of the immune systems of mice, scientists at Johns Hopkins Medicine say they have found a new role for a protein, QRICH1, which could become a target for drugs to dial up or down the activation of T cells to fight cancers and autoimmune diseases.

Medically Tailored Meal Programs Could Yield Significant Health Care Savings Across 49 U.S. States

Tufts University — Mon, 07 Apr 2025 16:00:00 EST

Simulation model estimates that Food is Medicine programs, if implemented nationwide, could save approximately $32.1 billion in health care costs in the first year alone and prevent more than 3.5 million hospitalizations annually related to complications from diabetes, heart disease, and cancer.

Home Care Cooperatives May Be Key to Addressing the Critical Shortage of Caregivers for the Elderly

University of California, Los Angeles (UCLA), Health Sciences — Mon, 07 Apr 2025 11:00:00 EST

Home care cooperatives may be the key to alleviating the shortage of paid caregivers for older Americans. Participants in cooperatives experienced more respect, control, job support, and compensation than their counterparts in traditional care services.

Alternative Approach to Lyme Disease Vaccine Development Shows Promise in Pre-Clinical Models

Tufts University — Mon, 07 Apr 2025 05:00:00 EST

Alternative approach to Lyme disease vaccine development shows promise in pre-clinical models

Chromatin Remodeling Captured in Comprehensive Structural Study

St. Jude Children's Research Hospital — Fri, 04 Apr 2025 18:15:00 EST

Scientists at St. Jude Children's Research Hospital used a series of cryo-EM structures to visualize dynamics pivotal to chromatin remodeling, a process implicated in cancer and developmental disorders.

Pancreatic Cells 'Remember' Epigenetic Precancerous Marks Without Genetic Sequence Mutations

Johns Hopkins Medicine — Fri, 04 Apr 2025 11:00:31 EST

Johns Hopkins Medicine scientists say they have found a pattern of so-called epigenetic "marks" in a transition state between normal and pancreatic cancer cells in mice, and that the normal cells may keep at least a temporary "memory" of those cancer-linked marks.

Research Uncovers Hidden Spread of One of the Most Common Hospital-Associated Infections

University of Utah Health — Fri, 04 Apr 2025 11:00:00 EST

C. difficile is one of the most common and contagious hospital-acquired infections. Research has found that C. diff spreads more than three times more than previously thought and can remain undetected on surfaces for weeks until it infects a patient.

How A Small Number of Mutations Can Fuel Outbreaks of Western Equine Encephalitis Virus

Harvard Medical School — Fri, 04 Apr 2025 11:00:00 EST

New research shows how small shifts in the molecular makeup of a virus can profoundly alter its fate. These shifts could turn a deadly pathogen into a harmless bug or supercharge a relatively benign virus, influencing its ability to infect humans and cause dangerous outbreaks.

Study Reveals Worse Patient Outcomes in Black-Serving Hospitals

University of Pennsylvania School of Nursing — Fri, 04 Apr 2025 10:35:45 EST

A new study - just published in Nursing Research - has uncovered concerning disparities in patient outcomes, specifically related to nursing care, within hospitals that predominantly serve Black communities.

Engineers Using 'Digital Twins' to Improve Agriculture, Health, Manufacturing and More

Iowa State University — Thu, 03 Apr 2025 20:35:52 EST

Iowa State researchers are building "digital twins" that are regularly updated with data from their physical twins. A national committee said digital twins have "immense promise in accelerating scientific discovery and revolutionizing industries."

News Curated ���Ҵ�ý Channel: Grant Funded News