蜜桃传媒

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Highlight:Exome sequencing (ES) is commonly used to diagnose Mendelian disorders, which occur when pathogenic variant(s) in a gene are either inherited from one or both parents or are de novo. Examples of such disorders include cystic fibrosis and sickle cell anemia. However, ES is not the first choice for detecting copy number variants (CNVs), which are typically deletions or duplications of DNA segments.

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We usually think about the mental health of older teens and adults. But what does mental health mean for babies? Marian E. Williams, PhD, Clinical Psychologist and Director of the Stein Tikun Olam Early Connections Program at Children鈥檚 Hospital Los Angeles, helps explain the concept of infant and early childhood mental health.

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Children鈥檚 Hospital Los Angeles announced that it has entered a strategic collaboration with Sidra Medicine, one of the leading hospitals for children and women in Qatar and the Middle East. The Memorandum of Understanding signed by the two institutions encompasses participation from multiple specialties across each healthcare organization, with the aim of enhancing shared best practices, advisory support, leading-edge research, patient care initiatives, education, and training.

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The ongoing shortage of donor hearts for children who need them stems from multiple causes, including a lack of donor awareness, organ allocation issues, and not enough organs that are of sufficient quality to transplant. Currently, new hearts for kids are still hard to find, and they are even scarcer for babies. Infants are particularly hard to match with a heart.

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A team led by Children鈥檚 Hospital Los Angeles has become the first in the world to demonstrate the possibility of using genetically engineered pig hearts as a potential 鈥渂ridge鈥� to heart transplant for critically ill babies. The groundbreaking preclinical research could lead to a lifesaving alternative for supporting critically ill babies waiting for a new heart鈥攑articularly those with single-ventricle heart disease, most of whom currently die while waiting for a transplant.

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The Amerman Family Foundation Dog Therapy Program at Children's Hospital Los Angeles hosted 鈥淒og Therapy Appreciation Day鈥� celebrating the special connection between CHLA and its therapy dog team.

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Children's Hospital Los Angeles is launching the first sleep registry in the country for children using Apple Watch as well as a new data collection app called WISE-HARE, or Wearable Intelligent Sensor Enhancement Home Apnea Risk Evaluation.

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Children鈥檚 Hospital Los Angeles experts are set to speak at nearly 80 sessions and poster presentations at the 2025 Pediatric Academic Societies (PAS) meeting April 24-28 in Honolulu.

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Researchers from Children鈥檚 Hospital Los Angeles and the USC Viterbi School of Engineering have received key funding to support their work on a novel device: an artificial right atrium for patients with a Fontan circulation. The investigators鈥擟ynthia Herrington, MD, and Andrew Cheng, MD, of CHLA, and Niema Pahlevan, PhD, of USC鈥攔eceived the USC Nemirovsky Engineering and Medicine Opportunity (NEMO) Prize.

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The Los Angeles City Fire Department (LAFD), the Advocacy Council and Allies for Deaf Children, and the Children鈥檚 Hospital Los Angeles University Center for Excellence in Developmental Disabilities (UCEDD) have developed a new curriculum, 鈥淭rauma-Informed Response to Children and Adults with Disabilities,鈥� specifically designed to guide first responders in supporting individuals with disabilities during natural disasters, such as this year鈥檚 L.A. wildfires.

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The Tikun Olam Foundation of the Jewish Community Foundation of Los Angeles has awarded a $25 million gift to establish the Stein Tikun Olam Early Connections Program at Children鈥檚 Hospital Los Angeles (CHLA). This program will be one of the first of its kind in the nation providing universal, hospital-wide infant-family mental health services. The transformational donation is the largest in the history of CHLA dedicated to early childhood mental health.

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Children's Hospital Los Angeles鈥� Liver Transplant Program has the best outcomes for pediatric liver transplants in the country.

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A CHLA specialist in infectious diseases explains the symptoms and sounds of whooping cough, and why vaccination is critical.

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Having a baby is a life-changing experience filled with emotion. It can bring great joy, fulfillment, and a sense of purpose, but also feelings of sadness, irritability, self-doubt, inadequacy, and exhaustion. When the negative feelings begin to outweigh the positives, a new parent might be experiencing postpartum depression.

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When a critically ill infant is admitted to the Steven & Alexandra Cohen Foundation Newborn and Infant Critical Care Unit (NICCU) at Children鈥檚 Hospital Los Angeles, it can be for an underlying genetic cause for the baby鈥檚 symptoms. The hard part is locating the malfunction in the genes involved. To help with this process鈥攁nd better tailor a baby's treatment鈥擟HLA is now providing genome sequencing for infants who present with complex and rare conditions.

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Measles is one of the world鈥檚 most contagious diseases. Thankfully, modern medicine provides an extremely effective tool against outbreaks, severe illness, and death.

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Parents of children who have been diagnosed with multiple sclerosis likely have many questions about their child鈥檚 condition. Receiving a diagnosis can be overwhelming and searching for information online can turn up complicated explanations.Laura Saucier, MD, MSc, a neuroimmunologist in the Neurological Institute at Children鈥檚 Hospital Los Angeles, breaks down the key information that parents should know about multiple sclerosis (MS).

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Are your household hazards 鈥渒id-proofed?鈥� It might sound silly, but one of the first things pediatrician Colleen Kraft, MD, tells families to do once their child is around 6 months old is crawl around the floor of their home: 鈥淧retend you're that 6-month-old. What looks interesting and dangerous to you? Because kids will beeline for that."

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Before she starts to break down what parents with sick newborns should look for in a neonatal intensive care unit (NICU), neonatologist Rachel Chapman, MD, says she first needs one key piece of information.鈥淚t depends on why you need a NICU,鈥� she says鈥攎eaning, how serious is your baby鈥檚 condition? Dr. Chapman is Medical Director of the Steven & Alexandra Cohen Foundation Newborn and Infant Critical Care Unit (NICCU) at Children鈥檚 Hospital Los Angeles.

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Ronald Ferdman, MD, MEd, Chief of Clinical Immunology and Allergy at Children鈥檚 Hospital Los Angeles, shares his advice on symptoms, diagnosis, and management and prevention tips for asthma.