Neutrophils, the most abundant immune cells in our bodies, are known for their destructive roles: killing pathogens, clearing out infections, and, sometimes to our detriment, wreaking havoc on surrounding tissues in the process.
After spending years tracing the origin and migration pattern of an unusual type of immune cell in mice, researchers have shown in a new study how activity of 鈥済ood鈥� microbes in the gut is linked to rheumatoid arthritis and, potentially, other autoimmune diseases.
More than 100 experts in molecular simulation, coordinated by IRB Barcelona, have published an article in Nature Methods advocating for a paradigm shift in molecular dynamics data management. The article defends the implementation of the FAIR principles (Findable, Accessible, Interoperable, Reusable) to improve the reproducibility of calculations and facilitate their later use as a source of information on the flexibility of biomacromolecules. Led by Drs. Modesto Orozco and Adam Hospital, the article proposes the establishment of a shared infrastructure for storing and reusing data in the context of the AI revolution.
How did horses become some of the greatest athletes in the animal kingdom? Researchers at Johns Hopkins Medicine may have found the answer, pinpointing a genetic mutation and evolutionary process that occurred millions of years ago, which appears to have optimized horses鈥� speeds and stamina.
Ulrich Steidl, M.D., Ph.D., professor and chair of cell biology at Albert Einstein College of Medicine and deputy director at the National Cancer Institute-designated Montefiore Einstein Comprehensive Cancer Center, has been elected a member of the Association of American Physicians (AAP), a prestigious 140-year-old honorary society dedicated to advancing medical knowledge through basic and clinical science.
A recent study has revealed that KIAA1199, a secreted protein produced by bone marrow cells, plays a crucial role in regulating both fat formation and overall energy metabolism. The protein's impact extends beyond bone remodeling, influencing glucose and lipid metabolism. Mice lacking KIAA1199 showed reduced fat mass, improved insulin sensitivity, and a decreased risk of obesity-related diseases. These findings suggest that targeting KIAA1199 could lead to new therapeutic strategies for combating metabolic disorders like obesity and type 2 diabetes.
乇賵鬲卮爻鬲乇貙 賲賷賳賷爻賵鬲丕 鈥� 賰卮賮鬲 丿乇丕爻丞 噩丿賷丿丞 賲賳 賲丕賷賵 賰賱賷賳賰 兀賳 丕賱兀卮禺丕氐 丕賱賲氐丕亘賷賳 亘賲鬲賱丕夭賲丞 鬲賵乇賷鬲 賷賲賱賰賵賳 毓丿丿賸丕 兀賯賱 亘賳爻亘丞 鬲氐賱 廿賱賶 50侏 賲賳 賳賵毓 賲丨丿丿 賲賳 禺賱丕賷丕 丕賱丿賲丕睾 丕賱鬲賷 鬲爻丕毓丿 賮賷 鬲賴丿卅丞 丕賱廿卮丕乇丕鬲 丕賱丨乇賰賷丞 丕賱賲賮乇胤丞貙 賲賯丕乇賳丞賸 亘丕賱兀卮禺丕氐 睾賷乇 丕賱賲氐丕亘賷賳. 賵賯丿 賷賰賵賳 賴匕丕 丕賱賳賯氐 爻亘亘賸丕 乇卅賷爻賷賸丕 賮賷 毓丿賲 賰亘丨 丕賱廿卮丕乇丕鬲 丕賱丨乇賰賷丞貙 賲賲丕 賷丐丿賷 廿賱賶 丕賱鬲卮賳噩丕鬲 丕賱賱丕廿乇丕丿賷丞 丕賱鬲賷 鬲購毓丿 丕賱爻賲丞 丕賱賲賲賷夭丞 賱賴匕丕 丕賱丕囟胤乇丕亘.
Scientists at St. Jude Children鈥檚 Research Hospital and the Medical College of Wisconsin have discovered how chemokines and G protein-coupled receptors selectively bind each other to control how cells move.
Un nuevo estudio de Mayo Clinic descubri贸 que las personas con s铆ndrome de Tourette poseen aproximadamente la mitad de un tipo espec铆fico de c茅lula cerebral responsable de calmar los signos de movimiento hiperactivo, en comparaci贸n con las personas sin la condici贸n. Este d茅ficit puede ser una raz贸n crucial por la cual las se帽ales motoras no se controlan adecuadamente, lo que lleva a los tics involuntarios que caracterizan el trastorno.
ProBio, a global contract development and manufacturing organization (CDMO), announced that it will present six poster presentations at the American Society of Gene and Cell Therapy (ASGCT) 28th Annual Meeting, taking place May 13鈥�15, 2025, in New Orleans, LA.
A new Mayo Clinic study finds that people with Tourette syndrome have about half as many of a specific type of brain cell that helps calm overactive movement signals as people without the condition. This deficit may be a key reason why their motor signals go unchecked, leading to the involuntary tics that define the disorder.
Capitalizing on the flexibility of tiny cells inside the body鈥檚 smallest blood vessels may be a powerful spinal cord repair strategy, new research suggests.
A team of researchers from the University of Chicago, in collaboration with researchers from the University of Pittsburgh, has identified a novel oncometabolite that accumulates in tumors and impairs immune cells' ability to fight cancer.
An international research collaboration led by Rutgers University-New Brunswick scientists that examined microscopic blobs of protein found in human cells has discovered that some morph from an almost honey-like substance to a hard candy-like solid. These mysterious droplets, known as biomolecular condensates, solidify when they carry a high proportion of the protein alpha-synuclein, the scientists reported in Science Advances. Clumps of alpha-synuclein are commonly found in the brain cells of people with Parkinson鈥檚 disease, a neurodegenerative brain disorder.
John N. Weinstein, M.D., Ph.D., chair of Bioinformatics and Computational Biology and professor of Systems Biology at The University of Texas MD Anderson Cancer Center, has been elected to the 2025 class of Fellows of the American Association for Cancer Research (AACR) Academy in recognition of decades of combined laboratory and computational work pioneering multi-omic molecular profiling, including the introduction of new laboratory techniques, clustered heat maps, and early innovations in artificial intelligence for cancer drug discovery.
A team of researchers successfully created more effective immune cells that can fight cancer without damaging healthy tissue.
Cell Therapy for Brain Tumors: Foundation Hosts Focused Ultrasound Roundtable
Fast, cost-effective identification of safe protein insertion sites could enable advanced biosensors and multi-functional proteins
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